Using a nanopore for single molecule detection and single cell transfection.
نویسندگان
چکیده
We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.
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عنوان ژورنال:
- The Analyst
دوره 137 13 شماره
صفحات -
تاریخ انتشار 2012